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The Role of Opioids in Pain Management is Evolving. Your Knowledge Should Evolve Too.

Fulfill your state-mandated CME credits and  ensure you know the latest guidelines and best practices for managing your patients' pain with a FREE NEJM Knowledge+ Pain Management and Opioids focus module.

  • Question bank created by clinicians, including pain management experts and addiction specialists.
  • Case-based questions reflect your everyday practice.
  • Learn today and put your knowledge to use immediately.

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Pain Management & Opioids Register for FREE

Over 60 engaging, case-based questions, with feedback, allow you to earn your required CME credits.

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NEJM Knowledge+ Pain Management and Opioids Lets You Earn Up to 10 AMA PRA Category 1 Credits™ with Learning Objectives that include:

  • The latest practices for assessing and managing acute and chronic pain.
  • Current guidelines on the appropriate use of opioids for pain management.
  • Evidence-based strategies for recognizing and treating opioid use disorder.

 NEJM Knowledge+ Pain Management and Opioids covers the entire FDA Education Blueprint for Health Care Providers Involved in the Treatment and Monitoring of Patients with Pain. 

Improve Your Clinical Confidence

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NEJM Knowledge+ is Different

NEJM Knowledge+ goes beyond passive reading and rote memorization. It actively tests your knowledge to help you truly master the material. Here are some of the reasons thousands of clinicians trust NEJM Knowledge+ to help them earn CME and MOC, pass their board exams, and improve their confidence and clinical judgement: 

  • Adaptive learning technology evaluates your performance to target areas where more review is needed, ensuring your knowledge is current, comprehensive, and complete.
  • Case-based questions, presented in multiple formats, keep you moving through the content in a challenging and enjoyable way.
  • Study anytime, anywhere, with bite-size learning that ensures that whether you have 3 minutes or 3 hours, your learning experience will be customized to your available time.
  • After you meet your CME requirements, you can continue to answer questions and review feedback in Pain Management & Opioids to keep your knowledge fresh.

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Build Your Clinical Confidence

Pain management is a balancing act: your patients' need for effective pain treatment is on one side and our nation's opioid epidemic is on the other. Safer, effective, and appropriate pain management is the fulcrum.

NEJM Knowledge+ Pain Management and Opioids can help you achieve that balance. It is the most effective way to review current, evidence-based clinical knowledge on opioid analgesics that complies with CDC guidelines.

Safer Prescribing Starts Here

Register for Pain Management and Opioids

NEJM Knowledge+ Pain Management and Opioids covers:

The fundamental concepts of pain management, including definitions and mechanisms of pain.

How to assess patients in pain, while identifying risk factors for abuse and addiction. 

The range of therapeutic options for managing pain, including non-pharmacologic approaches and pharmacologic (non-opioid and opioid analgesics) therapies.

How to integrate opioid analgesics into a pain treatment plan individualized to the needs of the patient.

How to safely and effectively manage patients on opioid analgesics in acute and chronic pain settings, including initiating therapy, titrating, and discontinuing use of opioid analgesics.

How to counsel patients and caregivers about the safe use of opioid analgesics, including proper storage and disposal.

How to counsel patients and caregivers about the use of naloxone for opioid overdose.

When referral to a pain specialist is appropriate.

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Your Partners in Medical Education

The new Pain Management and Opioids modules within NEJM Knowledge+ Internal Medicine Board Review and Family Medicine Board Review are offered in partnership with Boston University School of Medicine's Safer/Competent Opioid Prescribing Education (SCOPE of Pain) program. Thanks to an unrestricted educational grant as part of the FDA's mandated Risk Evaluation and Mitigation Strategy (REMS) program, NEJM Knowledge+ is able to make this new CME Module available for free. 

Approach Pain Management with Confidence

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 Accreditation Information 

  • Disclosure of support 
This activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies. Please see   for a listing of REMS Program Companies. This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the US Food and Drug Administration. 
  • Accreditation Statement

The Massachusetts Medical Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

The Massachusetts Medical Society designates this enduring material for a maximum 10 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

  • AMA Credit Designation Statement 
  • Risk Management and Pain Management Credits 

This activity meets the criteria of the Massachusetts Board of Registration in Medicine for risk management study.

This activity meets the criteria of the Massachusetts Board of Registration in Medicine for opioid education.

Several states have similar requirements. Please check with your Board to determine if this activity will fulfill your state's specific requirements. 

  • American Board of Internal Medicine MOC Points 

NEJM Knowledge+ Pain Management and Opioids (IM) only
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10 MOC points and patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. 

  • American Academy of Family Physicians (AAFP) 

NEJM Knowledge+ Pain Management and Opioids (FM) only
This Enduring Material activity, NEJM Knowledge+ Pain and Addiction Module, has been reviewed and is acceptable for up to 10 Prescribed credits by the American Academy of Family Physicians. AAFP certification begins (insert date). Term of approval is for one year from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

  • American Board of Medical Specialties Maintenance of Certification Part 2 Credit 

Through the American Board of Medical Specialties (“ABMS”) ongoing commitment to increase access to practice relevant Continuing Certification Activities through the ABMS Continuing Certification Directory,  NEJM Knowledge+ Pain Management and Opioids has met the requirements as an MOC Part II Self-Assessment and/or MOC Part II CME Activity (apply toward general CME requirement) for the following ABMS Member Boards:

MOC Part II CME Activity 


Family Medicine

Preventive Medicine

Psychiatry and Neurology


MOC Part II Self-Assessment Activity 

Physical Medicine and Rehabilitation

  • Credit Information for Nurse Practitioners

For the purposes of recertification, the American Academy of Nurse Practitioners Certification Board (AANPCB) accepts AMA PRA Category 1 Credit(s)™ issued by organizations accredited by ACCME as the number of hours of participation. Documentation of participation to non-physicians specifying the number of hours of participation is provided upon successful completion.

Please note: 1 CME Credit = 60 minutes or 1 contact hour, all of which are pharmacology credit-worthy.

  • NCCPA Accreditation Statement 

PAs may claim a maximum of 10 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. 

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