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Pain Management and Opioids CME

Fulfill Your Eight-Hour DEA Training Requirement for Opioid and Substance Use Disorders with One Free Program. 

Sixty-two (62) engaging, case-based questions, with feedback, learning resources, and clinical tools, allow you to earn your required CME credits.

NEJM Knowledge+ Pain Management and Opioids Lets You Earn Up to 10 AMA PRA Category 1 Credits™ with Learning Objectives that include:

 NEJM Knowledge+ Pain Management and Opioids covers the entire FDA Education Blueprint for Health Care Providers Involved in the Treatment and Monitoring of Patients with Pain. And satisfy the new one-time, eight-hour training requirement set forth by the (DEA).

NEJM Knowledge+ is Different

NEJM Knowledge+ goes beyond passive reading and rote memorization. It actively tests your knowledge to help you truly master the material. Here are some of the reasons thousands of clinicians trust NEJM Knowledge+ to help them earn CME and MOC, pass their board exams, and improve their confidence and clinical judgement: 

  • Adaptive learning technology evaluates your performance to target areas where more review is needed, ensuring your knowledge is current, comprehensive, and complete.
  • Case-based questions, presented in multiple formats, keep you moving through the content in a challenging and enjoyable way.
  • Study anytime, anywhere, with bite-size learning that ensures that whether you have 3 minutes or 3 hours, your learning experience will be customized to your available time.
  • After you meet your CME requirements, you can continue to answer questions and review feedback in Pain Management and Opioids to keep your knowledge fresh.

Ready to Experience the Benefits of NEJM Knowledge+?

Register for Pain Management and Opioids

Build Your Clinical Confidence

Pain management is a balancing act: your patients' need for effective pain treatment is on one side and our nation's opioid epidemic is on the other. Safer, effective, and appropriate pain management is the fulcrum.

NEJM Knowledge+ Pain Management and Opioids can help you achieve that balance. It is the most effective way to review current, evidence-based clinical knowledge on opioid analgesics that complies with CDC guidelines.

Safer Prescribing Starts Here

Pain Management and Opioids from NEJM Knowledge+ covers:

The fundamental concepts of pain management, including definitions and mechanisms of pain.

How to assess patients in pain, while identifying risk factors for abuse and addiction. 

The range of therapeutic options for managing pain, including non-pharmacologic approaches and pharmacologic (non-opioid and opioid analgesics) therapies.

How to integrate opioid analgesics into a pain treatment plan individualized to the needs of the patient.

How to safely and effectively manage patients on opioid analgesics in acute and chronic pain settings, including initiating therapy, titrating, and discontinuing use of opioid analgesics.

How to counsel patients and caregivers about the safe use of opioid analgesics, including proper storage and disposal.

How to counsel patients and caregivers about the use of medication for opioid overdose.

When referral to a pain specialist is appropriate.

 Accreditation Information 

  • Disclosure of Support
    This activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies. Please see for a listing of REMS Program Companies. This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the US Food and Drug Administration.
  • Accreditation Statement
    The Massachusetts Medical Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  • AMA Credit Designation Statement
    The Massachusetts Medical Society designates this enduring material for a maximum 10 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  • Risk Management and Pain Management Credits
    This activity meets the criteria of the Massachusetts Board of Registration in Medicine for risk management study.
    This activity meets the criteria of the Massachusetts Board of Registration in Medicine for opioid education.
    Several states have similar requirements. Please check with your Board to determine if this activity will fulfill your state's specific requirements. 
  • American Board of Internal Medicine MOC Points
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10 MOC points and patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  • American Board of Family Physicians (AAFP)
    The AAFP has reviewed NEJM Knowledge+ Pain Management and Opioids and deemed it acceptable for up to 10.00 Enduring Materials, Self-Study AAFP Prescribed credits. Term of Approval is from 04/15/2023 to 04/15/2024. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  • American Board of Medical Specialties Maintenance of Certification Part 2 Credit 
    Through the American Board of Medical Specialties (“ABMS”) ongoing commitment to increase access to practice relevant Continuing Certification Activities through the ABMS Continuing Certification Directory, NEJM Knowledge+ Pain Management and Opioids has met the requirements as an MOC Part II Self-Assessment and/or MOC Part II CME Activity (apply toward general CME requirement) for the following ABMS Member Boards:

    - MOC Part II Self-Assessment Activity
    Physical Medicine and Rehabilitation

    - MOC Part II CME Activity
    Family Medicine
    Preventive Medicine
    Psychiatry and Neurology
  • American Academy of PAs (AAPA)
    AAPA Category 1 Self Assessment CME Credits   
    This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 10.25 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation. Approval is valid from 4/15/2024 to 4/14/2025. AAPA reference number: CME-2011305.  
  • American Association of Nurse Practitioners
    Pharmacology Contact Hours
    This activity is approved for 10.0 contact hour(s) of continuing education (which includes 10.0 hours of pharmacology) by the American Association of Nurse Practitioners. Activity ID 23036011. This activity was planned in accordance with AANP Accreditation Standards and Policies
  • ACPE Credits
    The University of Rhode Island College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This is an application-based educational activity. Pharmacists will receive 8.0 contact hours (0.8 CEUS) for the educational activity. No partial credit is available. UNIVERSAL ACTIVITY NUMBERS (UAN) 0060-9999-22-055-H08-P

Ready to Experience the Benefits of NEJM Knowledge+?

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  • Question bank created by clinicians, including pain management experts and addiction specialists. 
  • Sixty-two question curated into eight topic areas for streamlined learning. 
  • Case-based questions, learning resources, and clinical tools reflect your everyday practice.
  • Offers ABIM and ABP MOC points.
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  • Choosing the most appropriate pain-management strategy for an individual patient. 
  • Recognizing the scenarios in which opioid analgesia is and is not appropriate. 
  • Recalling the importance of routinely assessing pain, function, and adverse effects in patient taking chronic opioid therapy. 
  • Identifying signs of opioid misuse and opioid use disorder. 
  • Choosing the most appropriate strategy for tapering or discontinuing opioid analgesics when necessary. 
  • Choosing the most appropriate intervention when opioid use disorder is suspected.